Research progress in preparation of nano antibacterial fiber by electrospinning

Chitosan nanofibers, (b) chitosan: shell poly c) chitosan: chitosan / d) chitosan: chitosan / columnar is the inhibition zone after different concentrations of Ag nanoparticle samples [58]. The neutralized electrospun fiber can completely kill the bacteria against methicillin-resistant Staphylococcus aureus (left) and Pseudomonas aeruginosa (right), and it has good antibacterial properties. . The antibacterial mechanism is that the silver ions in the CTS/SS/PVA/AgNO3 fiber mat are reduced in situ to nano-silver, which is adsorbed on the bacterial cell wall, which interferes with the permeability of the cell wall and hinders the respiration of bacteria. The composite functional antibacterial material is an electrospinning antibacterial agent and a material with special functions to prepare a fiber mat with various functions. Such functional materials mainly include collagen, polycaprolactone, polylactic acid, etc. Collagen is an ideal wound-assisted dressing. Collagen is biocompatible, degradable, and low in immunogenicity. It can be used as a good biological tissue scaffold [60]. BARNES et al [61] used electrospun hemoglobin/myoglobin fiber membranes as wound dressings and found that these fibers can transport oxygen and help repair injured tissue.
JAO et al [52] prepared a silk fibroin nanofiber mat containing TiO2 with a fiber diameter of 385-435 nm, which has good antibacterial effect against Gram-negative Escherichia coli and good blood compatibility. And fibroblasts [62] can grow normally on the fiber mat. The fiber felt obtained by electrospinning has better gas permeability and wound exudate absorption than conventional dressings. [63] A PAN-ZnO/Ag composite nanofiber film with photocatalytic, UV-resistant and antibacterial functions was prepared. 5 is the SEM of prepared ZnO composite nanofiber membranes with different morphologies. The prepared electrospun fiber membranes exhibit different degrees of photocatalytic efficiency and anti-ultraviolet function according to the morphology of ZnO, and the order is as follows: sea urchin type> flower type> pine cone shape. In the absence of light, PAN-ZnO/Ag composite nanofiber film still exhibits antibacterial properties against Staphylococcus aureus. It is clear that the material has a triple function and there is no interference between them. (a) pure PAN PAN - ZnO / Ag composite, (b) pineal, (c) flower, (d) sea urchin. Insertion is the SEM of the corresponding sample [62].
SEM for Electrospinning Preparation of Fibers In the field of new antibacterial materials, composite antibacterial fiber membranes have become a hot topic, especially for the study of functionalized antibacterial materials, biocompatible multifunctional antibacterial materials, such as repairing Tissue, cell growth scaffold function of the film is the main direction of research. However, the composite antibacterial materials currently developed have certain limitations, especially in terms of multi-functionality, the compatibility problem between other components and inorganic antibacterial agents has yet to be solved, which greatly hinders the practical application of composite antibacterial materials. . In addition, in the antibacterial process of composite antibacterial materials, although some studies have carried out biosafety tests on fibroblasts, it is still unclear whether it affects the life of normal cells under human condition.
Prospects and prospects Electrospinning technology is developing very rapidly. Although it is not yet fully industrialized, the improvement of the spinneret and receiving device has greatly promoted the scale-up of the process during the continuous research process [64] ]. However, in the process of electrospinning fiber mat, the thickness uniformity of the fiber mat and the uniformity of the pore size are difficult to control, which is an inherent feature of electrospinning, and also a major problem that the technology needs to solve in the amplification application. The new functional materials are environmentally friendly, efficient, and versatile, and are the current research hotspots. Antibacterial is an indispensable part of production and life. Antibacterial materials play an important role in the research of traditional materials and new materials.
At present, the research of antibacterial materials is also developing towards the research of new materials, especially the research of new antibacterial materials with versatility. Antibacterial materials tend to achieve antibacterial effects, and tend to achieve a variety of requirements such as controlled release, self-detection of antibacterial effects, such as antibacterial sustained release [65], mapping of antibacterial material color changes to antibacterial effects. Versatility is an inevitable trend in the development of materials, and electrospinning does not require solution components. Functional nanomaterials such as nanosensors, fluorescent display materials, and biomolecules can be used as additives to prepare electrospinning in combination with antibacterial materials. Nano-antibacterial materials of different dimensions. In summary, electrospinning is an advanced and effective technique for the preparation of new nano-antibacterial composites. UHEYT4UE9C

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